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KMID : 0614019990150010358
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Journal of Pharmaceutical Sciences (C.N.U.)
1999 Volume.15 No. 1 p.358 ~ p.363
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Evaluation of Thrombolytic Effect of Streptokinase-Dextran Conjugate in a Rat Model of Arterial Thrombosis
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Kim Yang-Woo
Kim Dong-Chool
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Abstract
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To evaluate the thrormbolyuc activity of streptokinase-dextran conjugate, a rat model of arterial thrombosis was used Briefly. the femoral artery was exposed and a filter paper saturated with 70% FeCl_3 situation was placed around the femoral artery in order to stop the blood flow six minutes after the stop of the blood flow in the femoral artery, strep-tokinase (10000~30000 units per rat)or streptokinase-dextran conjugate (5000~17000 units per rat) was administered by bolus injectionthrough the femoral vein Then the blood flow in the femoral artery was monitored using a Doppler laser flow meter The bolus administration of streptokinase-dextran conjugate could restore the blood flow in the femoral artery in the dose range of 5000~17000 units per rat A good correlation between the dose of streptokinase-dextran conjugate and the total thrombolyne effect was observed In addition, the lag time between the injection of streptokinase -dextran donjugate and the restoring of the blood flow was decreased as the dose of streptokinase-dextran conjugate increased. These resules show the supenor beneficiat effect of streptokicase-dextran conjugate compared with the inconjugated streprokinase with respect to the elongation of thrombolytic activity, the admanistration method(single injection versus continuous infusion) and the reduced dose necesarry for a equivalent thrombolytic effect .
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KEYWORD
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Streptokinase, Dextran, Conjugate, Arterial thrombolysis model
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